Lana Condor Ruby Gillman (voice) Toni Collette Agatha Gillman (voice) Annie Murphy Chelsea Van Der Zee (voice) Sam Richardson Uncle Brill (voice) Liza Koshy Margo (voice) Will Forte Gordon Lighthouse (voice) Colman Domingo Arthur Gillman (voice) Jaboukie Young-White Connor (voice) Blue Chapman Sam Gillman (voice) Ramona Young Bliss (voice) Eduardo Franco Trevin (voice) Jane Fonda Grandmamah (voice) Nicole Byer Janice (voice) Echo Kellum Doug (voice) Jordan Matter School Principal (voice) Ricardo Hurtado Student (voice)